University of Minnesota Develops Smartphone-Powered Microchip for At-Home Diagnostics and Telemedicine Platforms

Break through technology could make at-home diagnosis of diseases faster and more affordable.

A University of Minnesota Twin Cities research team has developed a new microfluidic chip for diagnosing diseases that uses a minimal number of components and can be powered wirelessly by a smartphone. The innovation opens the door for faster and more affordable at-home medical testing.

 

Nature Communications, a peer-reviewed, open-access scientific journal published by Nature Research, has published the study. Researchers are also striving to make the technology commercially viable.

Microfluidics is the study and manipulation of liquids at a microscopic level. Developing “lab-on-a-chip” technology, or the capacity to make devices that can detect diseases from a very little biological sample, such as blood or urine, is one of the most prominent applications in the area.

Scientists already have portable devices for diagnosing some conditions — rapid COVID-19 antigen tests, for one. However, a big roadblock to engineering more sophisticated diagnostic chips that could, for example, identify the specific strain of COVID-19 or measure biomarkers like glucose or cholesterol, is the fact that they need so many moving parts.

Chips like these would require materials to seal the liquid inside, pumps and tubing to manipulate the liquid, and wires to activate those pumps — all materials that are difficult to scale down to the micro level. Researchers at the University of Minnesota Twin Cities were able to create a microfluidic device that functions without all of those bulky components.

Researchers have been extremely successful when it comes to electronic device scaling, but the ability to handle liquid samples has not kept up. It’s not an exaggeration that a state-of-the-art, microfluidic lab-on-a-chip system is very labor intensive to put together. Our thought was, can we just get rid of the cover material, wires, and pumps altogether and make it simple?

Sang-Hyun Oh, Study Senior Author and Professor, Department of Electrical & Computer Engineering, University of Minnesota Twin Cities

Many lab-on-a-chip techniques identify virus pathogens or bacteria inside a sample by moving liquid droplets over a microchip. The method developed by the University of Minnesota researchers was inspired by a unique real-world occurrence that wine drinkers will be aware of: the “legs,” or lengthy droplets that form within a wine bottle owing to surface tension induced by alcohol evaporation.

Using a technique pioneered by Oh’s lab in the early 2010s, the researchers placed tiny electrodes very close together on a 2 cm by 2 cm chip, which generate strong electric fields that pull droplets across the chip and create a similar “leg” of liquid to detect the molecules within.

Because the electrodes are placed so closely together (with only 10 nanometers of space between), the resulting electric field is so strong that the chip only needs less than a volt of electricity to function. This incredibly low voltage required allowed the researchers to activate the diagnostic chip using near-field communication signals from a smartphone, the same technology used for contactless payment in stores.

This is the first time researchers have been able to use a smartphone to wirelessly activate narrow channels without microfluidic structures, paving the way for cheaper, more accessible at-home diagnostic device.

 

This is a very exciting, new concept during this pandemic, I think everyone has realized the importance of at-home, rapid, point-of-care diagnostics. And there are technologies available, but we need faster and more sensitive techniques. With scaling and high-density manufacturing, we can bring these sophisticated technologies to at-home diagnostics at a more affordable cost.

Christopher Ertsgaard, PhD, Study Lead Author, Department of Electrical & Computer Engineering, University of Minnesota. Ertsgaard is a recent CSE alumni (ECE PhD ‘20)

Oh’s lab is working with Minnesota startup company GRIP Molecular Technologies, which manufactures at-home diagnostic devices, to commercialize the microchip platform. The chip is designed to have broad applications for detecting viruses, pathogens, bacteria, and other biomarkers in liquid samples.

To be commercially successful, in-home diagnostics must be low-cost and easy-to-use. Low voltage fluid movement, such as what Professor Oh’s team has achieved, enables us to meet both of those requirements. GRIP has had the good fortune to collaborate with the University of Minnesota on the development of our technology platform. Linking basic and translational research is crucial to developing a pipeline of innovative, transformational products.

Bruce Batten, Founder and President, GRIP Molecular Technologies

In addition to Oh and Ertsgaard, the research team included University of Minnesota Department of Electrical and Computer Engineering alumni Daniel Klemme (Ph.D. ’19) and Daehan Yoo (Ph.D. ’16) and Ph.D. student Peter Christenson.

This research was supported by the National Science Foundation (NSF). Oh received support from the Sanford P. Bordeau Endowed Chair at the University of Minnesota and the McKnight University Professorship. Device fabrication was performed in the Minnesota Nano Center at the University of Minnesota, which is supported by NSF through the National Nanotechnology Coordinated Infrastructure (NNCI).

Journal Reference:
Ertsgaard, C. T., et al. (2022) Open-channel microfluidics via resonant wireless power transfer. Nature Communications. doi.org/10.1038/s41467-022-29405-2.

Stasia Ogden, JD

Stasia Ogden recently joined GRIP in a General Counsel role with a particular expertise in Intellectual Property Law.  Stasia has over 20 years as a practicing attorney in law firms and major multi-national corporations and 9 years with Baxter Healthcare Corporation and 4 years with BD.  Her focus on healthcare industry global IP strategy, transactions, licensing, litigation and global portfolio management will help GRIP navigate global IP issues and maximize existing rights to 3+ patent families that provide the foundation for GRIP’s novel electronic biosensor.  Stasia has a Juris Doctor degree from Georgetown University, an MBA from University of Missouri – St. Louis, and a BA in Biochemistry from Northwestern University in Chicago.

Michael Osterholm PhD

University of Minnesota Regents Professor 
  • McKnight Presidential Endowed Chair in Public Health 
  • Author
  • University of Minnesota
  • Director of the Center for Infectious Disease Research and Policy (CIDRAP)
  • Distinguished Teaching Professor in the Division of Environmental Health Sciences, School of Public Health and Technological Leadership Institute, College of Science and Engineering,
  • Medical School – Adjunct Professor
  • Science Envoy for Health Security on behalf of the US Department of State 2018-19
  • Numerous national/global Advisory Board appointments on Biosecurity, Health Research and Pandemics

Steven Koester PhD

Professor Electrical & Computer Engineering
University of Minnesota

Research Areas:

  • Graphene Biosensors
  • Biomedical & Biological Computational Methods
  • Energy Systems & Power Electronics
  • Micro and Nano structures 

Michael McAlpine, PhD

Professor Mechanical Engineering University of Minnesota

Research Areas:

  • 3D printing functional materials & devices
  • Advanced manufacturing using nanoscale inks
  • Biomedical devices
  • Bioelectronics

Edward Ludwig

  • 45+years of senior executive medical industry leadership experience
  •   Numerous Board roles, including with; Boston Scientific, CVS, Aetna, AdvaMed (Chairman), Johns Hopkins Michael Bloomberg School of Public Health, Hackensack University Medical Center, College of Holy Cross, Columbia Business School, The Center for Higher Ambition Leadership 
  • MBA – Columbia University

Laurie Knutson MBA

Vice President of Marketing

Laurie Knutson is GRIP’s VP of Marketing.  She bring over 30 years of healthcare strategy, product development and systems transformation experience across Fortune 50 to pre-revenue companies. Laurie has held C-level roles healthcare services, products, insurance, financial services and consulting, and was founder or C-level at 4 tech startups.  Laurie’s focus on commercializing products in the healthcare sector is based on her unique ability to assess the market and product adoption variables in areas of unmet needs. Laurie also has 10+ years analytics with care model development for seniors, commercial and vulnerable populations.  Laurie has her MBA in Finance from the University of Minnesota and her BA in Biology from St. Olaf College in Northfield, Minnesota.

Richard G Minicus MBA, MS

Rich Minicus is seasoned Chief Financial Officer with over 30 years in M&A, venture capital investment, and capital markets transactions. Rich brings 21 years in medical technology business development with Becton Dickinson, BD Ventures, and Pfizer which has enabled GRIP to quickly formulate a detailed financial plan beyond what most startups provide to investors. Rich also has 9 years in finance with Merrill Lynch Capital Markets, ML Venture Capital, and JP Morgan. Rich earned his MBA at Harvard Business School, and holds a MS in Biology from Fairleigh Dickinson University.

Caroline Popper

Caroline Popper, MD is the Co-Founder and President, Popper & Co. healthcare consultancy. Caroline has the perfect combination of 30 years’ experience in medical diagnostics and drug discovery, combined with extensive direct clinical experience. She has held many senior managerial and advisory positions with numerous global diagnostics companies, including BD, bioMérieux and MDS Proteomics. Caroline was also an attending physician at the Department of Emergency Medicine at Baltimore’s Johns Hopkins Hospital, where she completed residencies in internal medicine and pathology.

Edward Gillan

CEO, CCO

Ed Gillen is GRIP’s CEO and brings over 30 years medical device industry experience, including point-of-care diagnostics.  Ed enjoyed a successful 23-year career at Becton Dickinson (BD) holding many positions globally including WW Senior Director – Strategy & Business Development – Diabetes Care Division, Global VP/GM – Surgical and Anesthesia Systems ($200M P&L), Advanced Drug Delivery, Global Business Leader – Vaccine Delivery.  Ed’s startup experience includes his most recent role as CEO Medality Medical. Ed has his MBA from Penn State University.

disease diagnosis Grip molecular

Bruce Batten

Founder/Chairman/President

Bruce Batten has been founder / CEO of four technology startups including C-level roles at Thermo Instruments, CyberOptics and Advantek. Bruce started his career in Academia earning a Ph.D. in Anatomy & Cell Biology at the Medical College of Virginia, post-doctoral work at Harvard Medical School. He was Faculty member at Harvard, Tufts and The Ohio State medical schools and later ran the MBA Program at Augsburg University. Bruce has over 10 years of molecular diagnostic development, including detailed work on a POC Zika virus assay. Bruce founded GRIP Molecular to commercialize breakthrough solid state bioelectronic technology that will disrupt the diagnostic industry and empower consumers and doctors with fast, accurate and comprehensive information.

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